Mechanism of butyrate-induced vasorelaxation of rat mesenteric resistance artery
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Copper induces vasorelaxation and antagonizes noradrenaline-induced vasoconstriction in rat mesenteric artery.
BACKGROUND/AIMS Copper is an essential trace element for normal cellular function and contributes to critical physiological or pathological processes. The aim of the study was to investigate the effects of copper on vascular tone of rat mesenteric artery and compare the effects of copper on noradrenaline (NA) and high K(+) induced vasoconstriction. METHODS The rat mesenteric arteries were iso...
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Resveratrol has been shown to induce vasorelaxation. In this study, we investigated the mechanism(s) of resveratrol-induced vasorelaxation in resistance mesenteric arteries from male lean and dietary-induced obese rats. Compared with lean rats, arteries from dietary-obese rats showed significant (P<0.001) endothelial dysfunction, as indicated by a decrease (>20%) in maximal acetylcholine-induce...
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Physiological importance in vasodilator innervation alleviating noradrenergic neurogenic vasoconstriction has not been clarified. Isolated monkey mesenteric artery strips denuded of the endothelium responded to nerve stimulation by electrical pulses or nicotine with a contraction, which was potentiated by Ng-nitro-L-arginine, a nitric oxide synthesis inhibitor, but not by the D-enantiomer. The ...
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The aim of this study was to investigate the mechanisms underlying vasorelaxation induced by amodiaquine (AMQ) in rat superior mesenteric arteries. In normotensive, conscious rats, AMQ at 1-20 mg/kg i.v. produced hypotension and dose-dependent bradycardia. In mesenteric rings pre-contracted with phenylephrine (PHE) (10(-5) M), AMQ caused concentration-dependent relaxation [IC50 = (1.34 +/- 0.04...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1996
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1996.tb15200.x